Traffic. 2017 Jun;18(6):348-357. doi: 10.1111/tra.12483. Epub 2017 May 2.
Cell biology in China: Focusing on the lysosome.
Yang C1,2, Wang X3.
1 State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, Center for Life Sciences, and School of Life Sciences, Yunnan University, Kunming, China.
2 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
3 State Key Laboratory of Biomolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
The view that lysosomes are merely the recycling bins of the cell has changed greatly during recent years. Lysosomes are now known to play a central role in signal transduction, cellular adaptation, plasma membrane repair, immune responses and many other fundamental cellular processes. In conjunction with the seminal discoveries made by international colleagues, many important questions regarding lysosomes are being addressed by Chinese scientists. In this review, we briefly summarize recent exciting findings in China on lysosomal signaling, biogenesis, integrity and physiological functions.
autophagy-lysosome pathway; biogenesis; cell death; endo-lysosomal trafficking; lysosome secretion; lysosomes; membrane integrity; signaling