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张志刚


研究员/ zhangzhigang@ynu.edu.cn or zwolf2018@gmail.com/肠道微生物整合生物学研究

个人简历

1998.09-2002.07    内蒙古农业大学,农学学士

2003.09-2008.12    云南农业大学,农学博士

2009.02-2013.12    中国科学院昆明动物研究所,助理研究员

2014.01-2016.12    中国科学院昆明动物研究所,副研究员

2017.01-2019.05    中国科学院昆明动物研究所,研究员

2019.06-至今          云南大学,研究员

主要研究方向

研究方向为肠道微生物整合生物学研究。具体围绕不同动物类群,通过跨学科、大数据、多组学的整合生物学研究,来探讨动物肠道微生物与动物适应性性进化的关系,不仅要揭示肠道微生物-动物宿主协同进化的环境驱动力,也要发现影响动物表型进化的肠道微生态机制,为建立动物表型定向进化的肠道微生态干预策略提供理论依据和微生物资源。

1.动物肠道微生物与动物适应性性进化

适应性进化是进化生物学领域的研究热点。一直以来,大多数研究都是利用人或动物自身基因组的变异来探讨动物适应性进化的分子机制。近年来,越来越多的研究表明,除了动物自身基因组之外,动物的第二套基因组(肠道微生物组)在维持动物正常生理代谢、免疫、发育、认知等功能方面具有重要的作用,表明两套基因组(也被成为全基因组-Hologenomes”)及其相互作用有利于动物对极端环境或新环境的适应。因此,本研究方向重点是系统整合两套基因组信息,结合代谢组、蛋白组、培养组等组学工具,利用进化基因组学、系统生物学等多学科交叉的优势,探讨自然选择和人工选择下动物适应性进化的全基因组机制。

2.肠道微生物与多细胞动物宿主的协同进化

动物对极端环境或新环境的适应过程中,实际上也伴随着肠道微生物与动物宿主的长期协同进化,最终形成了互利共生(mutualism)、共生(symbiosis)、寄生(parasitism)三种互作关系。那么,理解肠道微生物与动物宿主如何协同进化进而形成上诉三种互作关系的机制机理,将有助于我们靶向肠道微生物,调控或干预动物宿主的健康和疾病。为此,本研究方向重点瞄准青藏高原哺乳动物类群,来探讨肠道微生物与动物宿主的协同进化机制,力求为靶向肠道微生物干预或调控动物复杂性状提供重要的进化生物学理论基础。

3. 以线虫、无菌小鼠、无菌猪以及灵长类动物为模型,探索肠道微生物干预或调控动物复杂性状的机制机理,比如长寿衰老、低氧适应、免疫促进等。

主要论文

1. Zhang Tao(#), Wu Qunfu(#), Zhang Zhigang(*). 2020. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Current Biology 30: 1346-1351.e1342. (*Correspondence author).

2. Wong G(*), Bi Y-H(*), Wang Q-H(*), Chen X-W(*), Zhang Zhigang(*), Yao Y-G(*). 2020. Zoonotic origins of human coronavirus 2019 (HCoV-19 / SARS-CoV-2): why is this work important? Zoological Research 41: 213. (*Co-correspondence author).

3. Li Z, Wright A-DG, Si H, Wang X, Qian W, Zhang Zhigang(*), Li G(*). 2016. Changes in the rumen microbiome and metabolites reveal the effect of host genetics on hybrid crosses. Environmental Microbiology Reports. DOI: 10.1111/1758-2229.12482. (*Co-correspondence author).

4. Yanhui Li, Cheng-Gang Zou, Yu Fu, Yanhong Li, Qin Zhou, Bo Liu, Zhang Zhigang(*), Juan Liu(*). Oral microbial community typing of caries and pigment in primary dentition. BMC Genomics, 2016, 17(1):1-11. (*Co-correspondence author).

5. Zhang Zhigang(#), Dongming Xu, Li Wang, Junjun Hao, JinFeng Wang, Xin Zhou, Weiwei Wang, Qiang Qiu, Xiaodan Huang, Jianwei Zhou, Ruijun Long(*), Fangqing Zhao(*), Peng Shi(*).Convergent evolution of rumen microbiomes in high-altitude mammals. Current Biology, 2016, 26 (14):1873-1879. (#First author).

6. Zhu, L., A.-H. Lei, H.-Y. Zheng, L.-B. Lyu, Zhang Zhigang(*) and Y.-T. Zheng(*). Longitudinal analysis reveals characteristically high proportions of bacterial vaginosis-associated bacteria and temporal variability of vaginal microbiota in northern pig-tailed macaques (Macaca leonina). Zoological Research, 2015, 36(5): 285-298. (*Co-correspondence author).

7. Li, Z., A.-D. G. Wright, H. Liu, Z. Fan, F. Yang, Zhang Zhigang(*) and G. Li(*). Response of the rumen microbiota of sika deer (Cervus nippon) fed different concentrations of tannin rich plants. PLoS ONE, 2015, 10(5): e0123481. (*Co-correspondence author).

8. Li Z, Wright A-D, Liu H, Bao K, Zhang T, Wang K, Cui X, Yang F, Zhang Zhigang(*), Li G(*).Bacterial community composition and fermentation patterns in the rumen of sika deer (Cervus nippon) fed three different diets. Microbial Ecology, 2015, 69(2): 307-318. (*Co-correspondence author).

9. Li, J., J. E. Powell, J. Guo, J. D. Evans, J. Wu, P. Williams, Q. Lin, N. A. Moran(*) and Zhang Zhigang(*). Two gut community enterotypes recur in diverse bumblebee species. Current Biology, 2015, 25(15): R652-R653. (*Co-correspondence author).

10. Zhang Zhigang(#), Geng J, Tang X, Fan H, Xu J, Wen X, Ma Z, Shi P. Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota. ISME J, 2014, 8(4): 881-893. (#First author)

11. Geng J, Song Q, Tang X, Liang X, Fan H, Peng H, Guo Q(*), Zhang Zhigang(*). Co-occurrence of driver and passenger bacteria in human colorectal cancer. Gut Pathogens, 2014, 6(1): 26. (* Co-correspondence author).

12. Zou T (#), Zhang Zhigang (#*), Zou C, Chen K, Dai Y, Tong J, Yu X, Liu J, Chen D, Xu H et al. Subclinical infections of cardiac implantable electronic devices: Insights into the host–bacteria dialog from blood and pocket tissue with pyrosequencing. International journal of cardiology, 2014, 174(3): 545-549. (*Co-correspondence author).

13. Ma L, Zou T, Yuan Y, Lv J, Dong X, Yang G, Zhu Y, Luo J, Zhang Zhigang(*), Yang J(*), Duodenal ferroportin is up-regulated in patients with chronic hepatitis C. PLoS ONE, 2014, 9(10): e110658. (*Co-correspondence author).

14. Li Z, Zhang Zhigang(*), Xu C, Zhao J, Liu H, Fan Z, Yang F, Wright A-DG, Li G(*). Bacteria and methanogens differ along the gastrointestinal tract of chinese roe deer (Capreolus pygargus. PLoS ONE, 2014, 9(12): e114513. (*Co-correspondence author).

15. Geng J, Fan H, Tang X, Zhai H, Zhang Zhigang(*). Diversified pattern of the human colorectal cancer microbiome. Gut Pathogens, 2013, 5(1): 2. (*Correspondence author).

16. Wu T(#), Zhang Zhigang(#), Liu B, Hou D, Liang Y, Zhang J, Shi P. Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study. BMC Genomics, 2013, 14(1): 669. (#Co-first author) (Highly Assessed).

17. Zhang Zhigang(*#), Zhai H, Geng J, Yu R, Ren H, Fan H(*), Shi P(*). Large-scale survey of gut microbiota associated with MHE via 16S rRNA-based pyrosequencing. Am J Gastroenterol, 2013, 108(10): 1601-1611. (*Co-correspondence author).