新萄京网址登录

孙建伟


教授(招生专业方向:细胞生物学)/ jwsun@ynu.edu.cn /线粒体功能调控与肿瘤发生

个人简介

 

工作单位:新萄京网址登录/生命科学中心

单位地址:昆明市呈贡区大学城东外环南路

编:650500

电子邮箱:jwsun@ynu.edu.cn

一、 个人情况介绍

博士、教授、博士生导师。2019年入选云南省千人计划青年人才项目资助,2021年入选云南省杰出青年基金项目资助。中国生物物理学会线粒体分会理事,以通讯/第一作者身份在Journal of Cell Biology、Oncogene、Journal of Biological Chemistry、Journal of cell science等国际一流学术期刊发表近20篇。

二、 教育经历

2006.09-2010.11   中国科学院遗传发育所 博士

2003.09-2006.07   青岛农业大学   硕士

1999.09-2003.07   青岛农业大学   学士

三、 工作经历

2019.01-至今 云南大学 新萄京网址登录 教授 博士生导师

2015.05 -2018.12   华南农业大学 新萄京网址登录 教授   博士生导师

2014.12 -2015.04   Moffitt癌症研究中心 研究科学家

2010.12 -2014.11   Moffitt癌症研究中心 博士后

四、研究方向

1. 钙池操纵的钙内流(SOCE)调控癌症发生及转移的分子机制

2. 肿瘤抗药性的机制研究

3. 线粒体功能调控失调在肿瘤发生中作用及机制

五、承担的科研项目

1. 云南省杰出青年基金(2021-2024)线粒体功能调控失调在肿瘤发生中作用及机制研究,金额:50万

2. 国家自然基金面上项目(2017-2020),STIM1/Orai1介导的钙池操纵的钙内流(soce)调控侵袭伪足形成的机制研究,基金编号:31671448,金额:60万

3. 云南省科技厅-云南大学双一流联合基金(2019-2022),STIM1-Pyk2信号通路在介导威罗菲尼(Vemurafenib)抗药性引起的黑色素瘤转移的作用机制研究,基金编号:2019FY003030,金额:65万

4. 云南大学启动基金(2019-2023),金额:200万

六、实验室成员

博士后:王兴顺;实验室助理:郝庆刚;博士生:桑磊;硕士生:赵信桦,严程浩,董瑞,陆梅

七、研究论文(*通讯作者)

1. Junling Shen, Jilong Yang, Rui Sun, Lei Sang, Weiyu Bai, Chao Wang, Yan Sun, Jianwei Sun*. BRAF V600E inhibitor vermurafenib induced melanoma cell invasion by activating STIM1- Pyk2 signaling axis and promoting invadopodia formation. Cancer Biology and Medicine. (2021, in press)

2. Lei Sang, Ying-jie He, Jiaxin Kang, Hongyi Ye, Weiyu Bai, Xiao-dong Luo and Jianwei Sun*. Mitochondrial deoxyguanosine kinase (DGUOK) regulates NAD+ Biogenesis Independent of mitochondria complex I activity. Frontiers in Oncology 2020 Dec 18;10:570656. doi: 10.3389/fonc.2020.570656

3. 桑磊,董瑞,陆梅,孙建伟*  Fascin:恶性肿瘤不良预后标志. 现代肿瘤医学. 2021

4. 孙瑞, 胡元昭, 商荣磊, 白韦钰 孙建伟*. 线粒体脱氧鸟苷激酶在肺癌肿瘤发生中的作用及机制研究 (中国科学:生命科学) . 2019, 49(7): 893-901

5. Jian Wang, Junling Shen, Kaili Zhao, Jinmeng Hu, Jiuxing Dong, Yan Sun and Jianwei Sun*. STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression. Cancer Biology and Medicine. 2019 Feb;16(1):100-108. doi: 10.20892/j.issn.2095-3941.2018.0304

6. Fujian Lu#, Jianwei Sun#, Qiaoxia Zheng, Jinghang Li, Yuanzhao Hu, Peng Yu, Huifang He, Yan Zhao, Xianhua Wang, Shengyu Yang* and Heping Cheng*. Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors. Journal of Cell Science (2019) 132, jcs224923. doi:10.1242/jcs.224923.

7. Jiaxin Kang, Jian Wang, Zhuang Yao, Yuanzhao Hu, Shijie MaQin FanYan Sun* and Jianwei Sun*. Fascin induce melanoma tumorgenesis and stemness through regulating TAZ stability. Cell Communication & Signaling. 2018 Jul 3;16(1):37. doi: 10.1186/s12964-018-0250-1.

8. Shengchen Lin#, Shuang Lu#, Mentor Mulaj, Bin Fang, Tyler Keeley, Lixin Wan, Jihui Hao, Martin Muschol, Jianwei Sun* and Shengyu Yang*. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin . Journal of Biological Chemistry. 2016 Dec 30;291(53):27323-27333.(*共同通讯作者)

9. Jaw-Yuan Wang#, Jianwei Sun#, Ming-Yii Huang, Ming-Feng Hou, Yu-Shiuan Wang, Yan Sun, Yao-Ting Tsai, Huifang He, Shengchen Lin, Shengyu Yang, and Wei-Chiao Chang.  STIM1 Overexpression promoted Colorectal Cancer Progression, Cell Motility and COX-2 Expression. (#共同第一作者) Oncogene, 2015 Aug 13;34(33):4358-67.

10. Jianwei Sun, Shengchen Lin, Tyler S Keeley, Shengyu Yang. Disseminating Melanoma Cells Surf on Calcium Waves. Molecular & Cellular Oncology. 2015;2(4). pii: e1002714

11. Jianwei Sun, Fujian Lu, Huifang He, Junling Shen, Jane Messina, Rahel Mathew, Dapeng Wang, Amod A. Sarnaik, Wei-Chiao Chang, Minjung Kim, Heping Cheng, and Shengyu Yang. STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion. Journal of Cell Biology. 2014 Nov 24, 207(4): 535-548. (Highlighted by JCB editor: http://jcb.rupress.org/content/early/2014/11/10/jcb.2074iti3)

12. Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan and Shengyu Yang. GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion. Journal of Biological Chemistry. 2013 Dec 27;288(52):36971-82.

13. Jianwei Sun, Huifang He, Yin Xiong, Shuang Lu, Junling Shen, Anna Cheng, Wei-Chiao Chang,Ming-Feng Hou, Johnathan M. Lancaster, Minjung Kim and Shengyu Yang. Fascin Protein Is Critical for Transforming Growth Factor Protein-induced Invasion and Filopodia Formation in Spindle-shaped Tumor Cells. Journal of Biological Chemistry 2011, 286(45): 38865–38875.

14. Mei Yang#, Jianwei Sun#, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao and Chonglin Yang. Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-induced Apoptosis. PLoS Genetics 2009 5(6):e1000514. (#共同第一作者)