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罗开珺


教授(招生专业方向:细胞生物学)/ kaijun_luo#ynu.edu.cn/免疫反应与细胞通讯调控机制

罗开珺  教授 

云南省高校细胞通讯调控国际合作重点实验室 主任430B7

招生方向:细胞生物学与生物化学

个人简历

2020年获云南省自然科学奖二等奖

2020年度获课堂教学优秀奖

2018年评为东陆学者

2017年晋升为三级教授

2016年荣获伍达观优秀教师奖先进奖

2010年云南省引进高层次人才

2010/08 – 至今,云南大学,新萄京网址登录,教授

2019/01 - 2019/12, 美国德州大学,圣安东尼奥健康科学中心,生物化学与结构生物学系,访问学者

2013/03 - 2013/06,  法国马赛大学,法国国家免疫研究中心,高级访问学者

2006/10 - 2009/07, 美国克莱蒙森大学,昆虫系,细胞生物学实验室,博士后

2001/09 - 2006/06中山大学,新萄京网址登录,硕博连读,博士

2003/07 - 2006/07, 云南省农业科学院,农业资源与环境研究所,副研究员

1998/07 - 2003/06, 云南省农业科学院,植物保护研究所,助理研究员

1992/07 - 1998/06, 云南省农业科学院,植物保护研究所,实习研究员

1988/09 - 1992/06, 云南师范大学,生物系,理学学士

主要研究方向:细胞通讯与免疫机制

Innexin-hemichannel-茧蜂病毒-免疫抑制相互作用机制

以无脊椎动物寄生蜂病毒-寄生蜂-寄主作为研究模式,研究在茧蜂病毒免疫抑制下hemichannel在细胞通讯调控作用,研究主要集中在:1)茧蜂病毒介导的hemichannel关闭与凋亡细胞形成凋亡小体的关系;2Hemichnanel在凋亡小体传递免疫抑制信号的作用;3)调控hemichannel在细胞通讯调控的害虫生物防治。

Connexin-hemichannel-脑转移-免疫反应相互作用机制

以云南宣威肺癌细胞的脑转移模式,研究Connexin-hemichannel在脑神经中枢的肿瘤免疫反应中的通讯调控机制,研究主要集中在:(1Hemichannel在宣威肺癌脑转移中的调控机制;(2Hemichannel在星形胶质细胞与肺癌细胞间的调控机制;(3)调控hemichannel在脑转移瘤细胞间的通讯机制,为肺癌脑转移的治疗提供实验基础。

实验室成员和在读研究生:

实验室成员:李明(副教授)、肖炜(副教授)、张旭东(讲师)、杨洋(实验师)、蔡秋宸科研助理)、代增美(养虫工人)

在读研究生:彭南楠、龙瑾、严祥李兴城、蔡成慧、孟江惠、唐红梅、刘宏瑜、陈昶旭、周贵芳、韩云风、张齐

教授课程:

本科生课程:《Principles of Virology (校级双语课)

Lehninger Principles of Biochemistry》,

《食品安全纵横谈》;

研究生课程:《Molecular Genetics》。         

主要论文

*Corresponding authors  

# These authors contributed equally to this work

1. Chang-Xu Chen#, Hao-Juan He#Qiu-Chen Cai#, Wei Zhang#, Tian-Chao KouXue-Wen ZhangShan You, Ya-Bin Chen, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo*. (2021) Bracovirus-mediated innexin-hemichannel closure in cell disassembly. iScience, Doi: 10.1016/j.isci.2021.102281

2. Qiu-Chen Cai#, Chang-Xu Chen#, Hong-Yu Liu#, Wei Zhang#, Yun-Feng Han, Qi Zhang, Gui-Fang Zhou, Sha Xu, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo*. (2021) Interactions of Vank proteins from Microplitis bicoloratus bracovirus with host Dip3 suppress eIF4E expression. Dev Comp Immunol, 103994. doi:https://doi.org/10.1016/j.dci.2021.103994

3. Chang-Xu Chen, Kai-Jun Luo*, Jia-Peng Yang, Yun-Chao Huang*, Eduardo R. Cardenas, Bruce J. Nicholson, and Jean X. Jiang* (2021). Connexins and cAMP cross-talk in cancer progression and metastasis. Cancers (Basel) 13. DOI: 10.3390/cancers13010058. https://encyclopedia.pub/7122

4. Kai-Jun Luo*, Chang-Xu Chen, Jia-Peng Yang, Yun-Chao Huang *, Eduardo R. Cardenas, and Jean X. Jiang * (2020). Connexins in Lung Cancer and Brain Metastasis. Frontiers in Oncology 10. DOI:10.3389/fonc.2020.599383

5. Ji-Hui Cui#, Shu-Mei Dong#, Chang-Xu Chen#, Wei Xiao#, Qiu-Cheng Cai, Li-Dan Zhang, Hao-Juan He, Wei Zhang, Xue-Wen Zhang, Tian Liu, Lei Ding, Yang Yang, Jian-Hua Lai, Qi-Shun Zhu, and Kai-Jun Luo*. (2019) Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura. Dev Comp Immunol 95, 101-107.

6. Li-Dan Zhang #, Qiu-Cheng Cai #, Ji-Hui Cui #, Wei Zhang #, Shu-Mei Dong #, Wei Xiao #, Jiang Li, Tian-Chao Kou, Xue-Wen Zhang, Hao-Juan He, Lei Ding, Yang Yang, Jian-Hua Lai, Ming Li, Qi-Shun Zhu, Kai-Jun Luo*. (2019) A secreted-Cu/Zn superoxide dismutase from Microplitis bicoloratus reduces reactive oxygen species triggered by symbiotic bracovirus. Dev Comp Immunol 92, 129-139.

7. Ji-Hui Cui #, Yan-Bin Chen #, Ming Li #, Qiu-Cheng Cai, Li-Dan Zhang, Zi-Yun Lu, Jian-Cheng Li, Qi-Shun Zhu, Gang Ji *, Kai-Jun Luo*. (2018) Cryo-EM structure reveals cylindrical nucleocapsids from two polydnaviruses. Arch Virol 163, 3357-3363.

8. Wei Zhang #, Meng-Wei Liu #, Ming Li #, Wei Xiao #, Xue-Wen Zhang Hao-Juan He, Yan-Bin Chen, Lei Ding, Kai-Jun Luo*. (2018) Unexpected link between insect innexins and apoptosis of HeLa cells. Arch Insect Biochem Physiol 99, e21473.

9. Shu-Mei Dong, Ji-Hui Cui, Wei Zhang, Xue-Wen Zhang, Tian-Chao Kou, Qiu-Chen Cai, Sha Xu, Dong-Shuai Yu, Lei Ding, Jian-Hua Lai, Ming Li, Kai-Jun Luo*. (2017). Inhibition of translation initiation factor eIF4A is required for apoptosis mediated by Microplitis bicoloratus bracovirus. Arch Insect Biochem Physiol 96, e21423.

10. Tian-Chao Kou #, Yue-Tong Liu #, Ming Li #, Yang Yang #, Wei Zhang, Ji-Hui Cui, Xue-Wen Zhang, Shu-Mei Dong, Sha Xu, Shan You, Dong-Shuai Yu, Zun-Yu Pang, Kai-Jun Luo*. (2017). Identification of β-chain of FoF1-ATPase in apoptotic cell population induced by Microplitis bicoloratus bracovirua and its role in the development of Spodoptera litura. Arch Insect Biochem Physiol 95, e21389

11. Dong-Shuai Yu #, Ya-Bin Chen #, Ming Li #, Ming-Jun Yang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). A polydnaviral genome of Microplitis bicoloratus bracovirus and molecular interactions between the host and virus involved in NF-κB signaling. Arch Virol 161, 3095-3125.

12. Ya-Bin Chen #, Wei Xiao #, Ming Li #, Yan Zhang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). N-terminally elongated SpliInx2 and SpliInx3 reduce baculovirus-triggered apoptosis via hemichannel closure. Arch Insect Biochem Physiol 92, 24-37.

13. Lin-E Guo #, Jun-Feng Zhang #, Xin-Yi Liu, Li-Mei Zhang, Hong-Li Zhang, Jian-Hua Chen, Xiao-Guang Xie, Ying Zhou*, Kai-Jun Luo*, Ju-Yong Yoon*. (2015) Phosphate ion targeted colorimetric and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell. Anal Chem 87, 1196-1201.

14. Zunyu Pang #Ming Li #Dongshuai Yu #Yan ZhangXinyi LiuXinglai JiYang YangJiansheng HuKaijun Luo*. (2015). Two innexins of Spodoptera litura influences hemichannel and gap junction functions in cellular immune responsesArch Insect Biochem Physiol 90, 43-57.

15. Ming Li #Zunyu Pang #Wei Xiao #Xinyi LiuYan ZhangMinjun YangYang YangJiansheng HuKaijun Luo*. (2014). A Transcriptome analysis Suggests apoptosis-related signaling pathways in hemocytes of Spodoptera litura after parasitization by Microplitis bicoloratusPLoS ONE 9(10),1-18, e110967.

16. Tian Liu #Ming Li #Yan ZhangZunyu PangWei XiaoYang YangKaijun Luo*. (2013). A role for Innexin2 and Innexin3 proteins from Spodoptera litura in apoptosis, PLoS ONE, 8(7), e70456.